IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells

@inproceedings{Chen2013IGFBP,
  title={IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells},
  author={Xiaoli Chen and Junke Zheng and Yizhou Zou and Chun Yu Song and Xuemei Hu and Cheng Cheng Zhang},
  booktitle={Journal of hematology & oncology},
  year={2013}
}
BACKGROUND The role of IGF binding protein 2 (IGFBP2) in cancer development is intriguing. Previously we identified IGFBP2 as an extrinsic factor that supports the activity of hematopoietic stem cells (HSCs). METHODS AND RESULTS Here we investigated the role of IGFBP2 in in human leukemia cells and in the retroviral AML1-ETO9a transplantation acute myeloid leukemia (AML) mouse model. RESULTS IGFBP2 is highly expressed in certain human AML and acute lymphoblastic leukemia (ALL) cells… CONTINUE READING
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