IGF and Insulin Receptor Signaling in Breast Cancer

Abstract

Major molecular abnormalities in breast cancer include the deregulation of several components of the IGF system. It is well recognized that the epithelial breast cancer cells commonly overexpress the IGF-I receptor while IGF-II is expressed by the tumor stroma. In view to the fact that the IGF-IR has mitogenic, pro-invasive and anti-apoptotic effects and… (More)
DOI: 10.1007/s10911-008-9099-z

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