IGF and GH mRNA levels are suppressed upon exposure to micromolar concentrations of cobalt and zinc in rainbow trout white muscle.

@article{Ekinci2011IGFAG,
  title={IGF and GH mRNA levels are suppressed upon exposure to micromolar concentrations of cobalt and zinc in rainbow trout white muscle.},
  author={Deniz Ekinci and Saltuk Buğrahan Ceyhun and Erc{\"u}ment Aksakal and Orhan Erdoğan},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2011},
  volume={153 3},
  pages={336-41}
}
The objective of this study was to assess the effects of cobalt and zinc exposure of rainbow trout (Oncorhynchus mykiss) on insulin like growth factors (IGF) and growth hormone (GH). Mature rainbow trouts were exposed to 0.42, 2.1, 4.2, 21 and 42μmol/L Co(2+) (added as CoCl(2)·6H(2)O) and 0.34, 1.7, 3.4, 17 and 34μmol/L Zn(2+) (added as ZnSO(4)i·7H(2)O). After 6, 12, 24 and 48h of treatment, expressions of white muscle IGF-I, IGF-II and GH mRNAs were measured by means of quantitative Real Time… CONTINUE READING

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