IGF-II promoter specific methylation and expression in epithelial ovarian cancer and their associations with disease characteristics.

@article{Qian2011IGFIIPS,
  title={IGF-II promoter specific methylation and expression in epithelial ovarian cancer and their associations with disease characteristics.},
  author={Biyun Qian and Dionyssios Katsaros and Lingeng Lu and Emilie Marion Canuto and Chiara Benedetto and Alicia Beeghly-Fadiel and Herbert Yu},
  journal={Oncology reports},
  year={2011},
  volume={25 1},
  pages={203-13}
}
High expression of insulin-like growth factor-II (IGF-II) in epithelial ovarian cancer is associated with aggressive disease and poor prognosis. IGF-II transcription is initiated from multiple promoters. Promoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer. Here, the effects of promoter-specific methylation on IGF-II expression are investigated in ovarian cancer. Fresh tumor samples were collected from 211 patients for analyses of IGF-II promoter… CONTINUE READING
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