IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1 phase cell cycle proteins.

Abstract

Autocrine production of insulin-like growth factor-I (IGF-I) regulates growth of human intestinal muscle cells by activation of distinct phosphatidylinositol 3-kinase (PI3-kinase)-dependent and ERK1/2-dependent pathways. The aim of the present study was to determine the mechanisms by which IGF-I regulates the G(1) phase of the cell cycle and muscle cell… (More)

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@article{Kuemmerle2004IGFISH, title={IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1 phase cell cycle proteins.}, author={John F Kuemmerle and Huiping Zhou and Jennifer G Bowers}, journal={American journal of physiology. Gastrointestinal and liver physiology}, year={2004}, volume={286 3}, pages={G412-9} }