IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1 phase cell cycle proteins.

@article{Kuemmerle2004IGFISH,
  title={IGF-I stimulates human intestinal smooth muscle cell growth by regulation of G1 phase cell cycle proteins.},
  author={John F Kuemmerle and Huiping Zhou and Jennifer G Bowers},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={286 3},
  pages={G412-9}
}
Autocrine production of insulin-like growth factor-I (IGF-I) regulates growth of human intestinal muscle cells by activation of distinct phosphatidylinositol 3-kinase (PI3-kinase)-dependent and ERK1/2-dependent pathways. The aim of the present study was to determine the mechanisms by which IGF-I regulates the G(1) phase of the cell cycle and muscle cell proliferation. Incubation of quiescent cells with IGF-I stimulated time-dependent cell cycle progression measured by using fluorescence… CONTINUE READING
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