IGF-I regulation of elastogenesis: comparison of aortic and lung cells.

@article{Rich1992IGFIRO,
  title={IGF-I regulation of elastogenesis: comparison of aortic and lung cells.},
  author={Celeste B. Rich and Daina Z. Ewton and Brian M. Martin and James R. Florini and Muhammad Mokarram Bashir and Joel Rosenbloom and Judith Ann Foster},
  journal={The American journal of physiology},
  year={1992},
  volume={263 2 Pt 1},
  pages={L276-82}
}
Rat neonatal aortic smooth muscle and pulmonary fibroblast cell cultures were exposed to different amounts of insulin-like growth factor-I (IGF-I, 1-100 ng/ml of medium) for 24 h. Aortic smooth muscle cells exhibited an increase in both steady-state levels of tropoelastin mRNA and soluble elastin with increasing amounts of IGF-I, suggesting that the growth… CONTINUE READING