IGF-I regulated phosphorylation and translocation of PDK-1 in neurons

@article{Alajajian2009IGFIRP,
  title={IGF-I regulated phosphorylation and translocation of PDK-1 in neurons},
  author={Betty B Alajajian and Lauren Fletcher and Elif Isgor and David F. Jimenez and Murat Digicaylioglu},
  journal={NeuroReport},
  year={2009},
  volume={20},
  pages={579-583}
}
3′-Phosphoinositide-dependent protein kinase-1 (PDK-1) is a crucial serine/threonine kinase in the insulin-like growth factor-I (IGF-I)/AKT signaling pathway, but its function and localization in the nervous system has not been fully characterized. In this study, we compared the localization of PDK-1 in adult neurons and non-neuronal PC-3 cells. We showed that PC-3 cells expressed phosphorylated and nonphosphorylated PDK-1 in the cytoplasm and nucleoplasm. In contrast, neuronal PDK-1 was… 
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