IGF-I receptor binding, autophosphorylation, and kinase activity in kidney and muscle of acutely uremic rats.

Abstract

Following acute tubular necrosis (ATN), kidney plasma membrane insulin-like growth factor-I (IGF-I) receptor number increases markedly, although IGF-I receptor mRNA levels do not change. To determine whether this increase could represent a redistribution of intracellular receptors and whether receptor function is intact in acute uremia, rats with ATN of 2… (More)

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