IGF-I is required for normal embryonic growth in mice.

@article{PowellBraxton1993IGFIIR,
  title={IGF-I is required for normal embryonic growth in mice.},
  author={Lyn Powell-Braxton and Philip G. Hollingshead and Corinna Warburton and Mary Dowd and Sharon Pitts-Meek and Dianne Dalton and Nancy A. Gillett and Timothy A. Stewart},
  journal={Genes & development},
  year={1993},
  volume={7 12B},
  pages={2609-17}
}
IGF-I is a pleiotropic hormone reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems. In contrast to IGF-II, IGF-I is expressed at low levels embryonically and has been thought to be more important for postnatal growth and development. To investigate the role of IGF-I in normal development we generated mice with an inactive IGF-I gene by homologous recombination in ES cells. Heterozygous mice are healthy and fertile, but they are 10-20… CONTINUE READING
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