IGF-I is required for normal embryonic growth in mice.

  title={IGF-I is required for normal embryonic growth in mice.},
  author={Lyn Powell-Braxton and Philip G. Hollingshead and Corinna Warburton and Mary Dowd and Sharon Pitts-Meek and Dianne Dalton and Nancy A. Gillett and Timothy A. Stewart},
  journal={Genes & development},
  volume={7 12B},
IGF-I is a pleiotropic hormone reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems. In contrast to IGF-II, IGF-I is expressed at low levels embryonically and has been thought to be more important for postnatal growth and development. To investigate the role of IGF-I in normal development we generated mice with an inactive IGF-I gene by homologous recombination in ES cells. Heterozygous mice are healthy and fertile, but they are 10-20… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
223 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 223 extracted citations

Similar Papers

Loading similar papers…