IGF-I is critical for normal vascularization of the human retina.

  title={IGF-I is critical for normal vascularization of the human retina.},
  author={Ann Hellstr{\"o}m and Bj{\"o}rn Carlsson and Aimon Niklasson and Karin Segnestam and Margaret C. S. Boguszewski and Luiz de Lacerda and Martin O. Savage and Elisabeth Svensson and Lois E. Smith and Dov Weinberger and Kerstin Albertsson Wikland and Z. V. I. Laron},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={87 7},
Experimental and clinical studies suggest that GH and IGF-I may be involved in neovascularization of the retina in diabetes and retinopathy of prematurity. However, the role of GH and IGF-I has not been well established in normal retinal vessel development in humans. Therefore, we examined retinal vessel morphology by digital image analysis of ocular fundus photographs in 13 patients with genetic defects of the GH/IGF-I axis and low levels of IGF-I during and after normal retinal vessel growth… CONTINUE READING
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Reference intervals of optic disc and retinal vessel variables in healthy children

  • A Hellström, E Svensson
  • Acta Ophthalmol
  • 1998

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