IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase.

@article{Beckert2006IGFIinducedVE,
  title={IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase.},
  author={Stefan Beckert and Farshid Farrahi and Q Perveen Ghani and Rummana S Aslam and Heinz Scheuenstuhl and Stephan Coerper and Alfred Koenigsrainer and Thomas K. Hunt and M. Zamirul Hussain},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={341 1},
  pages={67-72}
}
Insulin-like growth factor-I (IGF-I) has been shown to promote angiogenesis by enhancing vascular endothelial growth factor (VEGF) expression. However, how IGF-I-induces VEGF expression is not yet fully understood. With this investigation, we propose a new possible mechanism involving downregulation of poly(ADP-ribosyl)ation (pADPR). We first demonstrated that IGF-I increased VEGF protein expression in endothelial cells. Inhibitors of mitogen activated kinase (PD 98059), phosphatidyl-3-inositol… CONTINUE READING