IGF-I has a direct proliferative effect in adult hippocampal progenitor cells.

@article{berg2003IGFIHA,
  title={IGF-I has a direct proliferative effect in adult hippocampal progenitor cells.},
  author={Maria {\AA}berg and Nina {\AA}berg and Theo D. Palmer and Ann-Marie Alborn and Christine Carlsson-Skwirut and Peter Bang and Lars E. Rosengren and Torsten Olsson and Fred H. Gage and Peter S. Eriksson},
  journal={Molecular and cellular neurosciences},
  year={2003},
  volume={24 1},
  pages={23-40}
}
The aim of the present study was to investigate the potential direct effects of insulin-like growth factor-I (IGF-I) on adult rat hippocampal stem/progenitor cells (AHPs). IGF-I-treated cultures showed a dose-dependent increase in thymidine incorporation, total number of cells, and number of cells entering the mitosis phase. Pretreatment with fibroblast growth factor-2 (FGF-2) increased the IGF-I receptor (IGF-IR) expression, and both FGF-2 and IGF-I were required for maximal proliferation… CONTINUE READING
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