IGF-I and microglia/macrophage proliferation in the ischemic mouse brain.

@article{ODonnell2002IGFIAM,
  title={IGF-I and microglia/macrophage proliferation in the ischemic mouse brain.},
  author={Steven L O'Donnell and Terra J Frederick and J Kyle Krady and Susan J. Vannucci and Teresa L Wood},
  journal={Glia},
  year={2002},
  volume={39 1},
  pages={85-97}
}
We have used a model of hypoxic-ischemic brain injury in adult male C57BL/6 mice to study insulin-like growth factor-I (IGF-I) and IGF-binding protein (IGFBP) expression in response to cerebral hypoxia-ischemia (H/I) in the adult mouse. A period of 20 min of H/I that resulted in histopathology in cortex, striatum, and thalamus was correlated with induction of mRNA for IGF-I, IGFBP-2, IGFBP-3, IGFBP-5, and glial fibrillary acidic protein (GFAP) by 4 days of recovery. Increased IGF-I mRNA was… CONTINUE READING

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