IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts.

@article{Simmons2002IGFIAT,
  title={IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts.},
  author={James G. Simmons and Jolanta B. Pucilowska and Temitope O. Keku and Pauline Kay Lund},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={283 3},
  pages={
          G809-18
        }
}
Insulin-like growth factor I (IGF-I) and transforming growth factor-beta1 (TGF-beta1) are upregulated in myofibroblasts at sites of fibrosis in experimental enterocolitis and in Crohn's disease (CD). We compared the sites of expression of IGF-I and TGF-beta1 in a rat peptidoglycan-polysaccharide (PG-PS) model of chronic granulomatous enterocolitis and fibrosis. We used the human colonic CCD-18Co fibroblast/myofibroblast cell line to test the hypothesis that TGF-beta1 and IGF-I interact to… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 67 CITATIONS, ESTIMATED 54% COVERAGE

Evaluation of fibrosis in precision-cut tissue slices.

  • Xenobiotica; the fate of foreign compounds in biological systems
  • 2013
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

TGF-β1 and IGF-1 and Anastomotic Recurrence of Crohn’s Disease After Ileo-Colonic Resection

  • Journal of Gastrointestinal Surgery
  • 2008
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Immunological Basis of Inflammatory Bowel Disease

VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A new heterotopic transplant animal model of intestinal fibrosis.

  • Inflammatory bowel diseases
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of IGF-1 pathway in lung fibroblast activation

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2004
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations