IGF-I Stimulates In Vivo Thymopoiesis After Stem Cell Transplantation in a Child with Omenn Syndrome

@article{Ma2009IGFISI,
  title={IGF-I Stimulates In Vivo Thymopoiesis After Stem Cell Transplantation in a Child with Omenn Syndrome},
  author={Nina S. Ma and Ami J. Shah and Mitchell E Geffner and Neena Kapoor},
  journal={Journal of Clinical Immunology},
  year={2009},
  volume={30},
  pages={114-120}
}
ContextChildren with severe combined immunodeficiency who receive a T cell-depleted hematopoietic stem cell transplantation (HSCT) have delayed immune reconstitution.ObjectiveTo examine the use of recombinant human insulin-like growth factor-I (rhIGF-I) therapy to stimulate thymopoiesis after HSCT.Clinical caseA child with Omenn syndrome failed T cell reconstitution 6 months after HSCT. She started rhIGF-I therapy just before age 18 months. The initial dose (40 μg/kg twice daily) was increased… CONTINUE READING

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