IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).

Abstract

Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02-1.86), P = 0.01, and 1.44 (95% CI 1.04-1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60-1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50-1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57-1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19-1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women.

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@article{Rinaldi2006IGFIIA, title={IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC).}, author={Sabina Rinaldi and P. H. M. Peeters and Franco Berrino and Laure Dossus and Carine Biessy and Anja Weinreich Olsen and Anne Tjonneland and Kim Overvad and Francoise Clavel-Chapelon and M-C Boutron-Ruault and Bertrand T{\'e}hard and Gabriele Nagel and Jakob P Linseisen and H. Boeing and P H Lahmann and Antonia Trichopoulou and Dimitirios Trichopoulos and Maria Koliva and Domenico Palli and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and Carla H van Gils and Paulus A. H. van Noord and Diederick E Grobbee and HB Bueno-de-Mesquita and C . A . Gonz{\'a}lez and Antoni Agudo and M . D . Chirlaque and Aurelio Barricarte and Nerea Larra{\~n}aga Larra{\~n}aga and J . R . Quir{\'o}s and S. A. Bingham and Kay-Tee Khaw and Timothy J.A. Key and Naomi E. Allen and Annekatrin Lukanova and Nadia Slimani and Rodolfo Saracci and Elio Riboli and Rudolf Kaaks}, journal={Endocrine-related cancer}, year={2006}, volume={13 2}, pages={593-605} }