IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis

@article{Kleinberg2004IGFIAE,
  title={IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis},
  author={D. Kleinberg and Mark E. Feldman and W. Ruan},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={5},
  pages={7-17}
}
  • D. Kleinberg, Mark E. Feldman, W. Ruan
  • Published 2004
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • Growth hormone (GH)3 is essential for rodent mammary gland development during puberty.It binds to GH receptors in the stromal compartment of the mammary gland and stimulatesIGF-I mRNA expression. These findings lead to the hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structuresthat lead the process of mammary gland development during puberty. Subsequent studieshave in large measure proven this hypothesis. They include… CONTINUE READING
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