IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis

@article{Kleinberg2004IGFIAE,
  title={IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis},
  author={David L. Kleinberg and Mark Feldman and Weifeng Ruan},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2004},
  volume={5},
  pages={7-17}
}
Growth hormone (GH)3 is essential for rodent mammary gland development during puberty.It binds to GH receptors in the stromal compartment of the mammary gland and stimulatesIGF-I mRNA expression. These findings lead to the hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structuresthat lead the process of mammary gland development during puberty. Subsequent studieshave in large measure proven this hypothesis. They include… Expand
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Although the pubertal surge of estrogen is the immediate stimulus to mammary development, the action of estrogen depends upon the presence of pituitary growth hormone and the ability of GH to stimulate production of IGF-I in the mammary gland, which has been shown to stimulate a form of ductal morphogenesis, which is anatomically different from the kind induced by IGF-i and estradiol. Expand
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  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • 2008
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Data indicate that bGH works as well on mammary stromal tissue as on tissue with glands and suggests that GH acts on theStromal compartment of the mammary gland to induce IGF-I mRNA and possibly IGF- I itself, which, in turn, causes differentiation of epithelial ducts into terminal end buds. Expand
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TLDR
In situ hybridization analyses determined that IGF-I, IGF-II, and IGF-IR messenger RNAs were expressed in the highly proliferative terminal end buds during pubertal ductal growth and correlated with the pattern of rapidly proliferating cells, suggesting a potential autocrine or paracrine role for IGF- II as a mitogen for ductal epithelial cells. Expand
Early Mammary Development: Growth Hormone and IGF-1
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TLDR
This minireview focuses on the hormonal control of early mammary development with special emphasis on the roles of growth hormone and IGF-1. Expand
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