IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

@inproceedings{NietoEstvez2016IGFIAK,
  title={IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain},
  author={Vanesa Nieto-Est{\'e}vez and Çağla Defterali and Carlos Vicario-Abej{\'o}n},
  booktitle={Front. Neurosci.},
  year={2016}
}
The generation of neurons in the adult mammalian brain requires the activation of quiescent neural stem cells (NSCs). This activation and the sequential steps of neuron formation from NSCs are regulated by a number of stimuli, which include growth factors. Insulin-like growth factor-I (IGF-I) exert pleiotropic effects, regulating multiple cellular processes depending on their concentration, cell type, and the developmental stage of the animal. Although IGF-I expression is relatively high in the… CONTINUE READING
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