IGF-I/insulin hybrid receptors in human endothelial cells.

  title={IGF-I/insulin hybrid receptors in human endothelial cells.},
  author={Marloes Dekker Nitert and Simona I Chisalita and Karolina Olsson and Karin E Bornfeldt and Hans J Arnqvist},
  journal={Molecular and cellular endocrinology},
  volume={229 1-2},
Vascular complications are common in diabetes. IGF-I receptors (IGF-IR) and insulin receptors (IR) in endothelial cells might respond to altered levels of IGF-I and insulin, resulting in altered endothelial function in diabetes. We therefore studied IGF-IR and IR gene expression, ligand binding, receptor protein, and phosphorylation in human umbilical vein endothelial cells (HUVEC). IGF-IR mRNA was more abundant than IR mRNA in freshly isolated HUVEC (IGF-IR/IR ratio 7.1 +/- 1.5) and in… CONTINUE READING