IGF-I, TGF-beta, and BMP-4 are expressed during distraction osteogenesis of the pig mandible.

@article{Yates2002IGFITA,
  title={IGF-I, TGF-beta, and BMP-4 are expressed during distraction osteogenesis of the pig mandible.},
  author={Karen E. Yates and Maria Troulis and Leonard B. Kaban and Julie Glowacki},
  journal={International journal of oral and maxillofacial surgery},
  year={2002},
  volume={31 2},
  pages={173-8}
}
The mechanisms that regulate bone formation during distraction osteogenesis (DO) are not completely understood. Our hypothesis is that local cytokines that stimulate osteoblast activity are potential regulators of this process. The purpose of this study was to determine gene expression of insulin-like growth factor I (IGF-I), transforming growth factor-beta (TGF-beta), and bone morphogenetic protein 4 (BMP-4) in distracted wounds. A semiburied, rigid distraction device was placed across an… CONTINUE READING