IGF-I, IGF-II, IGF Binding Protein 1, and C-Peptide in Second Trimester Amniotic Fluid Are Dependent on Gestational Age but Do Not Predict Weight at Birth

@article{Verhaeghe1999IGFIII,
  title={IGF-I, IGF-II, IGF Binding Protein 1, and C-Peptide in Second Trimester Amniotic Fluid Are Dependent on Gestational Age but Do Not Predict Weight at Birth},
  author={Johan Verhaeghe and Willy Coopmans and Erik van Herck and Dominique van Schoubroeck and Jan Deprest and Ingrid Witters},
  journal={Pediatric Research},
  year={1999},
  volume={46},
  pages={101-108}
}
Previous data suggested that small for gestational age newborns have increased levels of IGF binding protein 1 (IGFBP1) in amniotic fluid (AF) at 15-16 wk of pregnancy. In this study, we developed an RIA for IGFBP1 and measured IGFBP1 concentrations in 209 AF samples with normal fetal karyotype between 14 and 20 wk; we measured IGF-I, IGF-II, and C-peptide in the same samples. Concentrations of these growth-modulating factors were all positively correlated with gestational age at sampling (p… CONTINUE READING