IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development

@article{Kleinberg2008IGFIGA,
  title={IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development},
  author={David L. Kleinberg and Weifeng Ruan},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2008},
  volume={13},
  pages={353-360}
}
  • D. KleinbergW. Ruan
  • Published 25 November 2008
  • Biology
  • Journal of Mammary Gland Biology and Neoplasia
Although the pubertal surge of estrogen is the immediate stimulus to mammary development, the action of estrogen depends upon the presence of pituitary growth hormone and the ability of GH to stimulate production of IGF-I in the mammary gland. Growth hormone binds to its receptor in the mammary fat pad, after which production of IGF-I mRNA and IGF-I protein occurs. It is likely that IGF-I then works through paracrine means to stimulate formation of TEBs, which then form ducts by bifurcating or… 
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References

SHOWING 1-10 OF 72 REFERENCES

IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis

The hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structure that lead the process of mammary gland development during puberty is proven.

Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.

It is possible that inhibition of IGF-I action, or perhaps GH, in the mammary gland may eventually play a role in breast cancer chemoprevention by preventing actions of both estrogen and progesterone, especially in women at extremely high risk for developing breast cancer such as BRCA gene 1 or 2 mutations.

Progesterone stimulates mammary gland ductal morphogenesis by synergizing with and enhancing insulin-like growth factor-I action.

Pg, through Pg receptor can enhance IGF-I action in DM, and E2 acts through a similar mechanism; E2 alone caused formation of ducts and side branches; there were differences in the actions of Pg and E 2, the former largely affecting duct formation and extension, and the latter side branching.

The Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins in Postnatal Development of Murine Mammary Glands

A role for the IGFs and IGFBPs are supported as local mediators of postnatal mammary gland growth and differentiation in mice mammary glands in organ culture.

The mammary gland.

  • I. Forsyth
  • Biology, Medicine
    Bailliere's clinical endocrinology and metabolism
  • 1991

The effect of GH on estrogen receptor expression in the rat mammary gland.

Analysis of mammary gland ER by immunocytochemistry demonstrated that while ER was present in the epithelial cells of non-treated animals, only GH treated animals had ER clearly visible in both glandular and fat cells of the tissue, whereas treating animals with des(1-3)-IGF-I did not result in reproducible increases in ER, nor in the staining of fat cell nuclei for ER.

Genetic manipulation of the IGF-I axis to regulate mammary gland development and function.

Analysis of early developmental processes in mammary tissue from mice carrying a targeted mutation in the IGF-I receptor gene suggests that IGF-dependent stimulation of cell cycle progression is more important to early mammary gland development than potential anti-apoptotic effects.

Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.

It is shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development, suggesting that GH receptors play a central role in this process.

Does an IGF-binding protein (IGFBP) present in involuting rat mammary gland regulate apoptosis?

The insulin-like growth factors (IGF) and IGF type I receptor during postnatal growth of the murine mammary gland: sites of messenger ribonucleic acid expression and potential functions.

Data support an in vivo role for locally-produced IGFs in promoting ductal growth during puberty and suggest that IGF-I and IGF-II may have distinct functions during pregnancy-induced alveolar development.
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