IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development

  title={IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development},
  author={D. Kleinberg and W. Ruan},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  • D. Kleinberg, W. Ruan
  • Published 2008
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • Although the pubertal surge of estrogen is the immediate stimulus to mammary development, the action of estrogen depends upon the presence of pituitary growth hormone and the ability of GH to stimulate production of IGF-I in the mammary gland. Growth hormone binds to its receptor in the mammary fat pad, after which production of IGF-I mRNA and IGF-I protein occurs. It is likely that IGF-I then works through paracrine means to stimulate formation of TEBs, which then form ducts by bifurcating or… CONTINUE READING
    63 Citations
    The pivotal role of insulin-like growth factor I in normal mammary development.
    • 29
    Mammary gland development--It's not just about estrogen.
    • 17
    Elevated circulating IGF-I promotes mammary gland development and proliferation.
    • 28
    • PDF
    Mammary gland growth factors: roles in normal development and in cancer.
    • 95
    • PDF
    Short communication: Expression of T-box 2 and 3 in the bovine mammary gland.
    • 2


    IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis
    • 179
    Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development.
    • 126
    • PDF
    Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.
    • 117
    • PDF
    The Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins in Postnatal Development of Murine Mammary Glands
    • 83
    The mammary gland.
    • I. Forsyth
    • Biology, Medicine
    • Bailliere's clinical endocrinology and metabolism
    • 1991
    • 208
    Genetic manipulation of the IGF-I axis to regulate mammary gland development and function.
    • 60
    The effect of GH on estrogen receptor expression in the rat mammary gland.
    • 35
    • PDF
    Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.
    • 116