IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development

@article{Kleinberg2008IGFIGA,
  title={IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development},
  author={David L. Kleinberg and Weifeng Ruan},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2008},
  volume={13},
  pages={353-360}
}
  • D. KleinbergW. Ruan
  • Published 25 November 2008
  • Biology
  • Journal of Mammary Gland Biology and Neoplasia
Although the pubertal surge of estrogen is the immediate stimulus to mammary development, the action of estrogen depends upon the presence of pituitary growth hormone and the ability of GH to stimulate production of IGF-I in the mammary gland. Growth hormone binds to its receptor in the mammary fat pad, after which production of IGF-I mRNA and IGF-I protein occurs. It is likely that IGF-I then works through paracrine means to stimulate formation of TEBs, which then form ducts by bifurcating or… 

The pivotal role of insulin-like growth factor I in normal mammary development.

Growth hormone potentiates 17β-estradiol-dependent breast cancer cell proliferation independently of IGF-I receptor signaling.

It is demonstrated that GH can have important effects in breast cancer cells that are distinct from IGF-IR activity, suggesting that novel drugs or improved combination therapies targeting estrogen receptor and the GH/IGF axis may be beneficial for breast cancer patients.

The role of the IGF system in mammary physiology of ruminants.

  • W. Cohick
  • Biology
    Domestic animal endocrinology
  • 2022

Mammary gland development--It's not just about estrogen.

The findings that dietary trans-10,cis-12 conjugated linoleic acid promotes ductal elongation and that the combination of progesterone and prolactin can stimulate branching morphogenesis in the absence of E are reviewed.

Elevated circulating IGF-I promotes mammary gland development and proliferation.

Animal studies have shown that IGF-I is essential for mammary gland development. Previous studies have suggested that local IGF-I rather than circulating IGF-I is the major mediator of mammary gland

Fetal alcohol exposure and mammary tumorigenesis in offspring: role of the estrogen and insulin-like growth factor systems.

Future studies will determine if fetal alcohol exposure can induce epigenetic modifications in genes that regulate E2/IGF action at key phases of mammary development, ultimately leading to changes in susceptibility to carcinogens.

TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Plasticity of mammary development in the prepubertal bovine mammary gland.

  • R. Akers
  • Medicine, Biology
    Journal of animal science
  • 2017
Development of new tools to identify, isolate, and characterize cell populations within the developing bovine mammary gland offer the possibility of identifying and perhaps altering populations of mammary stem cells or selected progenitor cells to modulate mammary development and, possibly, mammary function.
...

References

SHOWING 1-10 OF 72 REFERENCES

IGF-I: An Essential Factor in Terminal End Bud Formation and Ductal Morphogenesis

The hypothesis that GH acts through locallyproduced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structure that lead the process of mammary gland development during puberty is proven.

Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.

It is possible that inhibition of IGF-I action, or perhaps GH, in the mammary gland may eventually play a role in breast cancer chemoprevention by preventing actions of both estrogen and progesterone, especially in women at extremely high risk for developing breast cancer such as BRCA gene 1 or 2 mutations.

Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development.

Data indicate that bGH works as well on mammary stromal tissue as on tissue with glands and suggests that GH acts on theStromal compartment of the mammary gland to induce IGF-I mRNA and possibly IGF- I itself, which, in turn, causes differentiation of epithelial ducts into terminal end buds.

Progesterone stimulates mammary gland ductal morphogenesis by synergizing with and enhancing insulin-like growth factor-I action.

Pg, through Pg receptor can enhance IGF-I action in DM, and E2 acts through a similar mechanism; E2 alone caused formation of ducts and side branches; there were differences in the actions of Pg and E 2, the former largely affecting duct formation and extension, and the latter side branching.

The Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins in Postnatal Development of Murine Mammary Glands

A role for the IGFs and IGFBPs are supported as local mediators of postnatal mammary gland growth and differentiation in mice mammary glands in organ culture.

The mammary gland.

  • I. Forsyth
  • Biology, Medicine
    Bailliere's clinical endocrinology and metabolism
  • 1991

The effect of GH on estrogen receptor expression in the rat mammary gland.

Analysis of mammary gland ER by immunocytochemistry demonstrated that while ER was present in the epithelial cells of non-treated animals, only GH treated animals had ER clearly visible in both glandular and fat cells of the tissue, whereas treating animals with des(1-3)-IGF-I did not result in reproducible increases in ER, nor in the staining of fat cell nuclei for ER.

Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.

It is shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development, suggesting that GH receptors play a central role in this process.

The insulin-like growth factors (IGF) and IGF type I receptor during postnatal growth of the murine mammary gland: sites of messenger ribonucleic acid expression and potential functions.

Data support an in vivo role for locally-produced IGFs in promoting ductal growth during puberty and suggest that IGF-I and IGF-II may have distinct functions during pregnancy-induced alveolar development.
...