IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development

  title={IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development},
  author={David L. Kleinberg and Weifeng Ruan},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  • D. KleinbergW. Ruan
  • Published 25 November 2008
  • Biology
  • Journal of Mammary Gland Biology and Neoplasia
Although the pubertal surge of estrogen is the immediate stimulus to mammary development, the action of estrogen depends upon the presence of pituitary growth hormone and the ability of GH to stimulate production of IGF-I in the mammary gland. Growth hormone binds to its receptor in the mammary fat pad, after which production of IGF-I mRNA and IGF-I protein occurs. It is likely that IGF-I then works through paracrine means to stimulate formation of TEBs, which then form ducts by bifurcating or… 

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