IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

@inproceedings{Allard2018IGFBindingPW,
  title={IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?},
  author={John B. Allard and Cunming Duan},
  booktitle={Front. Endocrinol.},
  year={2018}
}
Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF-binding protein (IGFBP) family, of which six distinct types exist. These proteins bind to IGF with an equal or greater affinity than the IGF1 receptor and are thus in a key position to regulate IGF signaling globally and locally. Binding to an IGFBP… CONTINUE READING
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