IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

  title={IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice},
  author={Carla Lopes and M{\'a}rcio Ribeiro and Ana I Duarte and Sandrine Humbert and Fr{\'e}d{\'e}ric Saudou and Lu{\'i}s Pereira de Almeida and Michael Hayden and A Cristina Rego},
  journal={Molecular Neurobiology},
Huntington's disease (HD) is an autosomal dominant disease caused by an expansion of CAG repeats in the gene encoding for huntingtin. Brain metabolic dysfunction and altered Akt signaling pathways have been associated with disease progression. Nevertheless, conflicting results persist regarding the role of insulin-like growth factor-1 (IGF-1)/Akt pathway in HD. While high plasma levels of IGF-1 correlated with cognitive decline in HD patients, other data showed protective effects of IGF-1 in HD… CONTINUE READING
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49:1126–1142 pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt

  • S Humbert, EA Bryson, +5 authors F Saudou
  • Mol Neurobiol
  • 2014
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