IGF-1, IGFBP-1, and IGFBP-3 Polymorphisms Predict Circulating IGF Levels but Not Breast Cancer Risk: Findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)

@article{Patel2008IGF1IA,
  title={IGF-1, IGFBP-1, and IGFBP-3 Polymorphisms Predict Circulating IGF Levels but Not Breast Cancer Risk: Findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)},
  author={Alpa V. Patel and Iona Cheng and Frederico Canzian and Lo{\"i}c Le Marchand and Michael J. Thun and C. T. van den Berg and Julie E. Buring and Eugenia E. Calle and Stephen J. Chanock and Francoise Clavel-Chapelon and David G. Cox and Miren Dorronsoro and Laure Dossus and Christopher A. Haiman and Susan E. Hankinson and Brian E. Henderson and Robert Nathaniel Hoover and David J. Hunter and Rudolf Kaaks and Laurence N. Kolonel and Peter Kraft and Jakob P Linseisen and Eiliv Lund and Jonas Manjer and Catherine A. McCarty and P. H. Peeters and Malcolm C. Pike and Michael J Pollak and Elio Riboli and Daniel O. Stram and Anne Tjonneland and Ruth C. Travis and Dimitirios Trichopoulos and Rosario Tumino and Meredith Yeager and Regina G Ziegler and Heather Spencer Feigelson},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={197 - 209}
}
IGF-1 has been shown to promote proliferation of normal epithelial breast cells, and the IGF pathway has also been linked to mammary carcinogenesis in animal models. We comprehensively examined the association between common genetic variation in the IGF1, IGFBP1, and IGFBP3 genes in relation to circulating IGF-I and IGFBP-3 levels and breast cancer risk within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). This analysis included 6,912 breast cancer cases and 8,891 matched controls… CONTINUE READING