IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer.

@article{Yao2016IGFSTAT3NANOGSlugSA,
  title={IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer.},
  author={Chao Yao and Li Su and Juanjuan Shan and Chuanlin Zhu and Limei Liu and Chungang Liu and Yanmin Xu and Zhi Yang and Xiu-Wu Bian and Jimin Shao and Jianming Li and Maode Lai and Junjie Shen and Cheng Qian},
  journal={Stem cells},
  year={2016},
  volume={34 4},
  pages={820-31}
}
Discovery of epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are two milestones in people exploring the nature of malignant tumor in recent decades. Although some studies have presented the potential connections between them, the link details, underneath their superficial correlation, are largely unknown. In this study, we identified a small subpopulation of NANOG-positive colorectal cancer (CRC) cells, and demonstrated that they exhibited characteristics of CSCs and EMT… CONTINUE READING