IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

  title={IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis},
  author={Johanne Martel-Pelletier and J. Battista and Daniel Lajeunesse and J Pelletier},
  journal={Inflammation Research},
In the context of joint biology, insulin-like growth factor-1 (IGF-1) is the most likely candidate to affect the anabolism of cartilage matrix molecules. Mechanisms for controlling the effects of IGF-1 include alterations in the level of this growth factor, its receptor and/or the IGF-1 affinity or availability to its receptor. Disturbance of any one of the above elements may induce a disregulation of the mechanisms involved in the local control of joint tissue integrity. This review focuses on… CONTINUE READING


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