IFNs activate toll-like receptor gene expression in viral infections

@article{Miettinen2001IFNsAT,
  title={IFNs activate toll-like receptor gene expression in viral infections},
  author={Minja Miettinen and Timo Sareneva and Ilkka Julkunen and Sampsa Matikainen},
  journal={Genes and Immunity},
  year={2001},
  volume={2},
  pages={349-355}
}
Toll-like receptors (TLRs) mediate innate immune responses to microbes. TLR2, TLR5, TLR6, and TLR9 have been implicated in responses to bacterial components, and TLR4 is the receptor for Gram-negative bacteria. Recently, TLR4 was described to function in respiratory syncytial virus-induced NF-κB activation. Here we have analyzed TLR1–9 mRNA expression in human primary macrophages infected with influenza A and Sendai viruses. TLR1, TLR2, TLR4, TLR6, and TLR8 mRNAs were expressed at basal levels… 
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  • Biology, Medicine
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2011
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TLDR
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