IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation.

@article{Xiao2009IFNgammaPP,
  title={IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation.},
  author={Mingjie Xiao and Chunhui Wang and Jinhua Zhang and Zhiguang Li and Xueqiang Zhao and Zhihai Qin},
  journal={Cancer research},
  year={2009},
  volume={69 5},
  pages={2010-7}
}
IFNgamma plays a crucial role in immunity against a variety of transplanted tumors and methylcholanthrene-mediated tumorigenesis in mice. However, it is not clear whether and how endogenous IFNgamma influences 7,12-dimethylbenz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papilloma development. We found here that IFNgamma expression was markedly up-regulated shortly after DMBA/TPA application to the skin. Surprisingly, neutralizing IFNgamma activity in vivo… CONTINUE READING

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