IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis

@article{Kantarci2005IFNGPA,
  title={IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis},
  author={O H Kantarci and An Goris and David D Hebrink and Shirley V Heggarty and Stephen Cunningham and Iraide Alloza and Elizabeth J. Atkinson and Mariza de Andrade and Cynthia T McMurray and Colin A. Graham and Stanley A. Hawkins and Alfons Billiau and Benedicte Dubois and Brian G. Weinshenker and Koen Vandenbroeck},
  journal={Genes and Immunity},
  year={2005},
  volume={6},
  pages={153-161}
}
Interferon-gamma (IFNγ) treatment is deleterious in multiple sclerosis (MS). MS occurs twice as frequently in women as in men. IFNγ expression varies by gender. We studied a population-based sample of US MS patients and ethnicity-matched controls and independent Northern Irish and Belgian hospital-based patients and controls for association with MS, stratified by gender, of an intron 1 microsatellite [I1(761)*CAn], a single nucleotide polymorphism 3′ of IFNG [3′(325)*G → A] and three flanking… CONTINUE READING

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A populationbased association study of Fas and FasL polymorphisms in multiple sclerosis

OH Kantarci, DD Hebrink, SJ Achenbach
J Neuroimmunol • 2004

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