IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis.

@article{Vallinoto2010IFNGP,
  title={IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis.},
  author={Antonio Carlos Ros{\'a}rio Vallinoto and Ednelza S Graça and Mauro S{\'e}rgio Moura de Ara{\'u}jo and V{\^a}nia Nakauth Azevedo and Izaura Maria Vieira Cayres-Vallinoto and Luiz Fernando Almeida Machado and Marlu{\'i}sa de Oliveira Guimar{\~a}es Ishak and Ricardo Ishak},
  journal={Human immunology},
  year={2010},
  volume={71 7},
  pages={692-6}
}
Regarding the importance of interferon-gamma (IFN-gamma) in protective immunity against Mycobacterium tuberculosis and the functional role of IFNG +874T/A single nucleotide polymorphism (SNP) in the IFN-gamma production, the present study investigated the relationship of this genetic polymorphism with susceptibility to tuberculosis (TB). A total of 129 patients with pulmonary tuberculosis (PTB), 33 with extrapulmonary tuberculosis (EPTB), and 156 control subjects were studied. Blood samples… CONTINUE READING

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