IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function

@inproceedings{Ambjrn2013IFNB1interferoninducedAI,
  title={IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function},
  author={Malene Ambj\orn and Patrick Ejlerskov and Yawei Liu and Michael Lees and Marja J{\"a}{\"a}ttel{\"a} and Shohreh Issazadeh-Navikas},
  booktitle={Autophagy},
  year={2013}
}
IFNB1/interferon (IFN)-β belongs to the type I IFNs and exerts potent antiproliferative, proapoptotic, antiangiogenic and immunemodulatory functions. Despite the beneficial effects of IFNB1 in experimental breast cancers, clinical translation has been disappointing, possibly due to induction of survival pathways leading to treatment resistance. Defects in autophagy, a conserved cellular degradation pathway, are implicated in numerous cancer diseases. Autophagy is induced in response to cancer… CONTINUE READING

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