IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells.

Abstract

The PRR TLR7 plays a key role in the activation of autoantigen-reactive B cells. This response is increased markedly by IFN-α, produced by accessory cells, as a result of the up-regulation of TLR7. We report herein an alternative pathway by which TLR7 expression can be augmented. This finding was derived from continuation of ongoing studies to uncover… (More)
DOI: 10.1189/jlb.0212064

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