IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.

@article{Tamura2005IFNRF,
  title={IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.},
  author={Tomohiko Tamura and Prafullakumar Tailor and Kunihiro Yamaoka and Hee Jeong Kong and Hideki Tsujimura and John J O'Shea and Harinder Singh and Keiko Ozato},
  journal={Journal of immunology},
  year={2005},
  volume={174 5},
  pages={2573-81}
}
Dendritic cells (DCs) are bone marrow (BM)-derived APCs central to both innate and adaptive immunity. DCs are a heterogeneous cell population composed of multiple subsets with diverse functions. The mechanism governing the generation of multiple DC subsets is, however, poorly understood. In this study we investigated the roles of closely related transcription factors, IFN regulatory factor (IRF)-4 and IRF-8, in DC development by analyzing IRF-4(-/-), IRF-8(-/-), and IRF-4(-/-)IRF-8(-/-) (double… CONTINUE READING
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