IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.

@article{Stockinger2004IFNRF,
  title={IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.},
  author={Silvia Stockinger and Benjamin Reutterer and Barbara Schaljo and Carola Schellack and Sylvia Brunner and Tilo Materna and Masahiro Yamamoto and Shizuo Akira and T. Taniguchi and Peter J Murray and Mathias Mueller and Thomas Decker},
  journal={Journal of immunology},
  year={2004},
  volume={173 12},
  pages={7416-25}
}
Like viruses, intracellular bacteria stimulate their host cells to produce type I IFNs (IFN-alpha and IFN-beta). In our study, we investigated the signals and molecules relevant for the synthesis of and response to IFN by mouse macrophages infected with Listeria monocytogenes. We report that IFN-beta is the critical immediate-early IFN made during infection, because the synthesis of all other type I IFN, expression of a subset of infection-induced genes, and the biological response to type I… CONTINUE READING

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