IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.

@article{Fragale2008IFNRF,
  title={IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.},
  author={Alessandra Fragale and Lucia Gabriele and Emilia Stellacci and Paola Borghi and Edvige Perrotti and Ramona Ilari and Angela Lanciotti and Anna Lisa Remoli and Massimo Venditti and Filippo Belardelli and Angela Battistini},
  journal={Journal of immunology},
  year={2008},
  volume={181 3},
  pages={1673-82}
}
Regulatory T (Treg) cells are critical in inducing and maintaining tolerance. Despite progress in understanding the basis of immune tolerance, mechanisms and molecules involved in the generation of Treg cells remain poorly understood. IFN regulatory factor (IRF)-1 is a pleiotropic transcription factor implicated in the regulation of various immune processes. In this study, we report that IRF-1 negatively regulates CD4(+)CD25(+) Treg cell development and function by specifically repressing Foxp3… CONTINUE READING

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