IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation.

@article{Krug2002IFNproducingCR,
  title={IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation.},
  author={Anne Krug and Ravindra Uppaluri and Fabio F. Facchetti and Brigitte G. Dorner and Kathleen C. F. Sheehan and Robert D Schreiber and Marina Cella and Marco Colonna},
  journal={Journal of immunology},
  year={2002},
  volume={169 11},
  pages={6079-83}
}
Human natural IFN-producing cells (IPC) circulate in the blood and cluster in chronically inflamed lymph nodes around high endothelial venules (HEV). Although L-selectin, CXCR4, and CCR7 are recognized as critical IPC homing mediators, the role of CXCR3 is unclear, since IPC do not respond to CXCR3 ligands in vitro. In this study, we show that migration of murine and human IPC to CXCR3 ligands in vitro requires engagement of CXCR4 by CXCL12. We also demonstrate that CXCL12 is present in human… CONTINUE READING