IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

@article{Snapper1988IFNgammaSI,
  title={IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.},
  author={Clifford M Snapper and Christian Peschel and William E. Paul},
  journal={Journal of immunology},
  year={1988},
  volume={140 7},
  pages={2121-7}
}
rIFN-gamma strikingly enhances the secretion of IgG2a by murine splenic B cells stimulated with bacterial LPS in vitro and concomitantly suppresses the production of IgG3, IgG1, IgG2b, and IgE while sparing IgM secretion. IFN-gamma stimulates highly purified B cell populations to secrete IgG2a, strongly suggesting that it acts directly on B cells. It increases the frequency of precursors of IgG2a-expressing soft agar colonies and enhances the number of IgG2a+ cells in colonies indicating that… CONTINUE READING