IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.

@article{Malmberg2002IFNgammaPS,
  title={IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.},
  author={K J Malmberg and Victor Levitsky and H{\aa}kan R. Norell and Cristina Teixeira de Matos and Mattias Carlsten and Kjell Schedvins and Hodjattallah Rabbani and Alessandro Moretta and K. -O. S{\"o}derstr{\"o}m and Jelena Levitskaya and Rolf Kiessling},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 10},
  pages={1515-23}
}
IFN-gamma regulates the immunogenicity of target cells by increasing their expression of HLA class I molecules. This facilitates the T cell receptor-mediated recognition by CD8(+) T cells but decreases target cell sensitivity to lysis by NK cells due to engagement of inhibitory NK receptors. In this study, short-term tumor cell lines from patients with advanced ovarian carcinomas were established. We demonstrate the paradoxical finding that IFN-gamma treatment of these short-term ovarian… CONTINUE READING

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