IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides.

@article{Yi1996IFNgammaPI,
  title={IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides.},
  author={A K Yi and J H Chace and John S. Cowdery and Arthur M. Krieg},
  journal={Journal of immunology},
  year={1996},
  volume={156 2},
  pages={558-64}
}
Lymphocyte recognition of characteristic structural features in microbial DNA may contribute to immune defense by promoting protective immune responses. The dinucleotide CpG is significantly under-represented in vertebrate DNA and is usually methylated. In contrast, CpG dinucleotides are generally present at the expected frequency in bacterial DNA and are unmethylated. These unmethylated CpG motifs induce B cells to secrete IL-6 and IgM, and can induce NK and CD4+ T cells to produce the… CONTINUE READING

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The dinucleotide CpG is significantly under - represented in vertebrate DNA and is usually methylated .
Mice with disrupted IFN - gamma genes produced less than half as much IL-6 and IgM in response to CpG DNA , supporting the hypothesis that CpG - induced IFN - gamma production contributes to the B cell response .
Mice with disrupted IFN - gamma genes produced less than half as much IL-6 and IgM in response to CpG DNA , supporting the hypothesis that CpG - induced IFN - gamma production contributes to the B cell response .
Interferon Type IIGene product expressed in tissueNatural Killer Cells
These results indicate that IFN - gamma produced by T and NK cells after CpG DNA stimulation contributes to the B cell production of IL-6 and the subsequent Ig production .
These unmethylated CpG motifs induce B cells to secrete IL-6 and IgM , and can induce NK and CD4 + T cells to produce the immunoregulatory Th1 cytokine , IFN - gamma .
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