Corpus ID: 6369002

IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells.

@article{Roth2004IFNgammaPF,
  title={IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells.},
  author={E. Roth and H. Pircher},
  journal={Journal of immunology},
  year={2004},
  volume={172 3},
  pages={
          1588-94
        }
}
To study liver cell damage by CTL, CD8 T cells from P14 TCR transgenic (tg) mice specific for the gp33 epitope of lymphocytic choriomeningitis virus with either deficiency in IFN-gamma (P14.IFN-gamma(null)), functional Fas ligand (P14.gld), or perforin (P14.PKO) were transferred into H8 tg mice ubiquitously expressing gp33 Ag. Treatment of H8 recipient mice with agonistic anti-CD40 Abs induced vigorous expansion of the transferred P14 T cells and led to liver cell destruction determined by… Expand
Cytotoxic Effector Function of CD4-Independent, CD8+ T Cells Is Mediated by TNF-&agr;/TNFR
This information is current as Injury Mediated Immune Hepatic − γ A-Induced IFN-Glycogen Synthase Kinase-3 Facilitates
Antiviral T Cell Response Triggers Cytomegalovirus Hepatitis in Mice
...
1
2
3
...