IFN-gamma production by innate immune cells is sufficient for development of hypersensitivity pneumonitis.

@article{Nance2005IFNgammaPB,
  title={IFN-gamma production by innate immune cells is sufficient for development of hypersensitivity pneumonitis.},
  author={Stephanie C Nance and Richard A. Cross and A E Yi and Elizabeth A. Fitzpatrick},
  journal={European journal of immunology},
  year={2005},
  volume={35 6},
  pages={1928-38}
}
Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to inhaled particulate antigens. The disease is characterized by lymphocytic alveolitis, granuloma formation and fibrosis. IFN-gamma is required for the formation of granulomas in HP, and we therefore focused on identifying the cellular sources of IFN-gamma during the disease. Using the Saccharopolyspora rectivirgula (SR) animal model of HP, we demonstrated that the majority of IFN-gamma… CONTINUE READING
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