IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA.

@article{Uchijima2005IFNgammaOL,
  title={IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA.},
  author={Masato Uchijima and Toshi Nagata and Taiki Aoshi and Yukio Koide},
  journal={Immunology and cell biology},
  year={2005},
  volume={83 1},
  pages={
          92-5
        }
}
Dendritic cells (DC) are professional APC that have an extraordinary capacity to prime naive T cells. It has been reported that human DC subsets express distinct toll-like receptor (TLR), which influences their function. In mice, we observed that plasmocytoid DC (pDC) express a higher level of TLR9 compared with myeloid DC (mDC) cultured with GM-CSF. However, we demonstrated that stimulation with IFN-gamma is capable of upregulating TLR9 expression in mDC to a level comparable with expression… CONTINUE READING
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