IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer.

@article{Martini2010IFNgammamediatedUO,
  title={IFN-gamma-mediated upmodulation of MHC class I expression activates tumor-specific immune response in a mouse model of prostate cancer.},
  author={Matteo Martini and Maria Grazia Testi and Matteo Pasetto and Maria Cristina Picchio and Giulio Innamorati and Marta Mazzocco and Stefano Ugel and Sara Cingarlini and Vincenzo Bronte and Paola Zanovello and Mauro Krampera and Federico Mosna and Tiziana Cestari and Anna Pia Riviera and Nadia Brutti and Ottavia Barbieri and Lina Matera and Giuseppe Tridente and Marco Colombatti and Silvia Sartoris},
  journal={Vaccine},
  year={2010},
  volume={28 20},
  pages={3548-57}
}
De novo expression of B7-1 impaired tumorigenicity of TRAMP-C2 mouse prostate adenocarcinoma (TRAMP-C2/B7), but it did not elicit a protective response against TRAMP-C2 parental tumor, unless after in vitro treatment with IFN-gamma. TRAMP-C2 cells secrete TGF-beta and show low MHC-I expression. Treatment with IFN-gamma increased MHC-I expression by induction of some APM components and antagonizing the immunosuppressant activity of TGF-beta. Thus, immunization with TRAMP-C2/B7 conferred… CONTINUE READING
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