IFN-gamma-mediated survival enables human neutrophils to produce MCP-1/CCL2 in response to activation by TLR ligands.

@article{Yoshimura2007IFNgammamediatedSE,
  title={IFN-gamma-mediated survival enables human neutrophils to produce MCP-1/CCL2 in response to activation by TLR ligands.},
  author={Teizo Yoshimura and Munehisa Takahashi},
  journal={Journal of immunology},
  year={2007},
  volume={179 3},
  pages={1942-9}
}
TLRs are key elements of the pathogen recognition mechanism used by the host immune system. Neutrophils express almost all TLRs, and activation of TLRs, such as TLR2 and TLR4, has been shown to induce the production of proinflammatory cytokines and chemokines, potentially linking innate and adaptive immunity. In the present study, we investigated whether… CONTINUE READING