IFN-gamma induces transglutaminase 2 expression in rat small intestinal cells.

  title={IFN-gamma induces transglutaminase 2 expression in rat small intestinal cells.},
  author={Soo Youl Kim and Eun-Joo Jeong and Peter M. Steinert},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={22 6},
Transglutaminase 2 (tissue transglutaminase, TGase 2) was recently identified as an endomysial autoantigen in celiac disease (CD). Identification of how TGase 2 expression is increased may allow a better understanding of this autoimmune disease. Certain inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta), and the Th type I cytokine interferon-gamma (INF-gamma) are abundant in CD. We have investigated whether these play a role in the… CONTINUE READING


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