IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism.

@article{RendonMitchell2003IFNgammaIH,
  title={IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism.},
  author={Beatriz Rendon-Mitchell and Mahendar Ochani and Jianhua Li and Jialian Han and Hong Wang and H. -S. Yang and Seenu M Susarla and Christopher J. Czura and Robert Mitchell and Guoqian Chen and Andrew E. Sama and Kevin J Tracey and Haichao Wang},
  journal={Journal of immunology},
  year={2003},
  volume={170 7},
  pages={
          3890-7
        }
}
We recently discovered that a ubiquitous protein, high mobility group box 1 protein (HMGB1), is released by activated macrophages, and functions as a late mediator of lethal systemic inflammation. To elucidate mechanisms underlying the regulation of HMGB1 release, we examined the roles of other cytokines in induction of HMGB1 release in macrophage cell cultures. Macrophage migration inhibitory factor, macrophage-inflammatory protein 1beta, and IL-6 each failed to significantly induce the… CONTINUE READING