IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2.

@article{Ttemeyer2006IFNgammaEP,
  title={IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2.},
  author={Sabine S T{\"o}temeyer and Mark Sheppard and Adrian Lloyd and David Roper and Christopher G. Dowson and David Underhill and Peter Murray and Duncan J Maskell and Clare Bryant},
  journal={Journal of immunology},
  year={2006},
  volume={176 8},
  pages={4804-10}
}
Pattern recognition receptors are central to the responsiveness of various eukaryotic cell types when they encounter pathogen-associated molecular patterns. IFN-gamma is a cytokine that is elevated in humans and other animals with bacterial infection and enhances the LPS-induced production of antibacterial mediators by macrophages. Mice lacking the pattern recognition receptor, TLR4, respond very poorly to stimulation by LPS, but administration of IFN-gamma has been described as restoring… CONTINUE READING

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