Corpus ID: 46130661

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

  title={IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.},
  author={A. Wensky and G. Furtado and M. Marcondes and S. Chen and D. Manfra and S. Lira and D. Zagzag and J. Lafaille},
  journal={Journal of immunology},
  volume={174 3},
  • A. Wensky, G. Furtado, +5 authors J. Lafaille
  • Published 2005
  • Medicine
  • Journal of immunology
  • Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4(+) T cells. EAE classically presents with a progressive ascending paralysis and is a model of multiple sclerosis that recapitulates some aspects of the disease. In this report we describe a mouse strain that spontaneously develops a severe, nonclassical form of EAE with 100% incidence. The distinct clinical phenotype is marked initially by a slight head tilt, progressing to a… CONTINUE READING
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