IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

@article{Wensky2005IFNgammaDD,
  title={IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.},
  author={Allen K. Wensky and Glaucia C Furtado and Maria Cecilia Garibaldi Marcondes and Shaohua Chen and Denise Manfra and Sergio A Lira and David Zagzag and Juan J Lafaille},
  journal={Journal of immunology},
  year={2005},
  volume={174 3},
  pages={
          1416-23
        }
}
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4(+) T cells. EAE classically presents with a progressive ascending paralysis and is a model of multiple sclerosis that recapitulates some aspects of the disease. In this report we describe a mouse strain that spontaneously develops a severe, nonclassical form of EAE with 100% incidence. The distinct clinical phenotype is marked initially by a slight head tilt, progressing to a… CONTINUE READING

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